Organic sulfuric acids and derivatives
Medchemexpress LLC Chondroitin sulfate (from pig) | 9007-28-7 | 95.1% | 5 G
Chondroitin sulfate from pig is a biochemical reagent suitable as a biological material or organic compound for life science research. This product is for research use only and not for patient use. It appears as an off-white to light yellow solid with a purity of 95.06%.
- Suitable for life science related research
- Can be used as a biological material or organic compound
- Off-white to light yellow solid appearance
- Purity of 95.06%
- Formula: (C14H21NO14S)n
- Store at 4°C, protected from light
- For solutions, store at -80°C for 6 months or -20°C for 1 month, protected from light
- Solubility in H2O is 100 mg/mL (requires ultrasonic)
Medchemexpress LLC Selumetinib sulfate | 943332-08-9 | 99.58% | C17H17BrClFN4O7S | 1 G
Selumetinib sulfate is a selective, non-ATP-competitive oral MEK1/2 inhibitor, with an IC50 of 14 nM for MEK1. It inhibits ERK1/2 phosphorylation and can penetrate the blood-brain barrier (BBB).
- Causes a time- and dose-dependent reduction in DNA synthesis and cell viability
- Induces growth arrest and apoptosis associated with the inactivation of ERK in primary cells
- Shows anti-proliferative effects through G0/G1 arrest
- Results in growth inhibition of cell lines containing B-Raf and Ras mutations
- Decreases the growth rate of xenografts in a dose-dependent manner
- Suppresses the growth of xenografts
- Inhibits ERK1/2 phosphorylation and growth of xenograft tumors in nude mice
- Tumor regressions observed in xenograft models
eMolecules 6638-79-5 | N,O-Dimethyl hydroxylamine hydrochloride | Oakwood Chemical | MFCD00012485 | 97.540 | C2H8ClNO | 98.000 | Cl.CNOC | 1kg | 648635995
N,O-Dimethyl hydroxylamine hydrochloride | Oakwood Chemical | 6638-79-5 | MFCD00012485 | 97.540 | C2H8ClNO | 98.000 | Cl.CNOC | 1kg | 648635995
Medchemexpress LLC Vinblastine (sulfate) | 143-67-9 | 99.86% | 909.05 | 100 MG
Vinblastine sulfate is a cytotoxic alkaloid that targets various cancer types by inhibiting microtubule formation and suppressing nAChR (IC50 8.9 μM). It blocks mitosis (IC50 0.8 nM in HeLa cells), leading to cell apoptosis. For storage, keep sealed at 4°C, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month, similarly sealed. Room temperature shipping is suitable for durations under 2 weeks.
- Inhibits microtubule formation.
- Suppresses nAChR with an IC50 of 8.9 μM.
- Blocks mitosis, leading to cell apoptosis.
- Induces apoptosis via Bax/Bcl-2 imbalance.
- Suppresses NFκB expression and depresses NFκB-DNA binding activity.
- Triggers apoptosis by causing a loss of mitochondrial membrane potential and activating caspases.
Apexbio Technology LLC Vinblastine sulfate 143-67-9 50mg
Vinblastine sulfate (CAS 143-67-9) is a bioactive small molecule that exerts antitumor effects primarily by disrupting microtubule formation a critical process for cell division Additionally vinblastine inhibits neuronal nicotinic acetylcholine receptor (nAChR) activity exhibiting an IC50 of 8 9 M In vitro studies demonstrated cytotoxicity with EC50 values around 15 g/mL against P815 mastocytoma cells Clinical research continues to explore vinblastine sulfate both as a monotherapy and within chemotherapeutic combinations investigating treatment protocols for metastatic melanoma and other cancers
Medchemexpress LLC Cefpirome sulfate | 98753-19-6 | MFCD08234364 | 99.0% | 612.66 g/mol | C22H24N6O9S3 | 10 MG
Cefpirome sulfate is an analytical reference material of cefpirome, a fourth-generation cephalosporin antibiotic. The substance is supplied as a light yellow to yellow solid with identity confirmed by 1H NMR and mass spectrometry, and accompanied by a certificate of analysis reporting HPLC purity and assay results. Stored sealed and dry at 4°C, it is intended for research and analytical applications.
Apexbio Technology LLC Phenyl sulfate 937-34-8 25mg
Phenyl sulfate (CAS 937-34-8) is a protein-bound uremic solute implicated in oxidative stress-related cellular injury It accumulates in patients with chronic kidney disease (CKD) inducing reactive oxygen species generation and diminishing intracellular glutathione levels Studies using porcine renal tubular cells demonstrated that phenyl sulfate enhances vulnerability to oxidative damage significantly amplifying hydrogen peroxide-induced cytotoxicity In murine models with diabetic kidney disease (KKAy mice on high-fat diets) phenyl sulfate administration intensified albuminuria and structural renal damage including podocyte effacement and basement membrane alterations Consequently phenyl sulfate serves as a biomarker in CKD research useful in assessing interventions targeting protein-bound uremic toxins
Medchemexpress LLC Cefoselis sulfate (FK-037) | 122841-12-7 | MFCD01940015 | 99.4% | 50 MG
Cefoselis sulfate (FK-037) is a fourth-generation cephalosporin and a β-lactam antibiotic known for its broad-spectrum activity. It is effective against a wide range of both Gram-positive and Gram-negative organisms. A key feature of this compound is its ability to penetrate the blood-brain barrier.
- Demonstrates good activity against a broad spectrum of Gram-positive and Gram-negative organisms.
- Ability to penetrate the blood-brain barrier.
- Functions as a fourth-generation cephalosporin and β-lactam antibiotic.
- High purity.
Medchemexpress LLC Ceftolozane sulfate | 936111-69-2 | 99.7% | 764.77 | 5 MG
Ceftolozane (CXA-101) sulfate is an antipseudomonal cephalosporin. It binds to P. aeruginosa essential PBPs (1b, 1c, 2 and 3) with high affinity and inhibits cell wall synthesis. Ceftolozane sulfate inhibits P. aeruginosa and Enterobacteriaceae.
- Antibacterial activity against fully AmpC-derepressed P. aeruginosa
- Antipseudomonal activity against carbapenem-resistant and MDR isolates
- Reduces ESBL-producing Enterobacteriaceae in neutropenic mice
- Reduces bacterial load and improves early pulmonary inflammatory response in a mice model of Pseudomonas aeruginosa acute pneumonia
eMolecules 264231-28-9 | diethyl 12-bromodecylphosphonate | Broadpharm | MFCD11046105 | 385.323 | C16H34BrO3P | 98.000 | CCOP(=O)(CCCCCCCCCCCCBr)OCC | 500mg | 550804379
diethyl 12-bromodecylphosphonate | Broadpharm | 264231-28-9 | MFCD11046105 | 385.323 | C16H34BrO3P | 98.000 | CCOP(=O)(CCCCCCCCCCCCBr)OCC | 500mg | 550804379